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Biased agonism in the mu-opioid receptor Prof. Martinez-Mayorga et.al.
In this webinar we will talk about G-protein-biased agonism of the mu-opioid receptor (μ-OR). The design of μ-OR biased ligand is emerging as a promising strategy in analgesia. A deep understanding of how biased agonists modulate and differentiate G-protein-coupled receptors (GPCR) signalling pathways and how this is transferred into the cell are open questions. Using extensive all-atom molecular dynamics simulations, we suggest a structural mechanism of biased signalling in μ-OR. Notably, we show the archetype modulator of μ-OR. The interactive pattern of the archetype modulator of μ-OR is valuable for the screening of new biased agonists.
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